At the 31st Annual Meeting of the Chinese Society of Dermatology, the academic monograph Atlas of Two-Photon Microscopy for Skin Diseases was officially launched.
Published by People’s Medical Publishing House, the book is the first comprehensive atlas in China dedicated to the clinical application of two-photon microscopy in dermatology. Edited by Professor Yong Cui and reviewed by Professor Rusong Meng, the atlas brings together extensive multicenter clinical experience and represents a significant milestone in the advancement of dermatological imaging in China.
Advancing Non-Invasive Optical Biopsy
For decades, dermatology has benefited from continuous innovations in imaging technologies—from dermoscopy and high-frequency ultrasound to reflectance confocal microscopy. While these modalities have significantly improved visualization of skin structures, most remain focused on morphological assessment.
Two-photon microscopy introduces a new dimension by enabling the simultaneous observation of morphology, tissue composition, and cellular function in vivo. Utilizing femtosecond near-infrared laser excitation, the technology captures endogenous fluorescence and second-harmonic generation signals without the need for tissue excision or staining, providing high-resolution, subcellular imaging of living skin.
The publication systematically introduces the principles, operation, and clinical applications of two-photon microscopy, covering 34 common dermatological conditions and featuring 72 high-quality in vivo imaging cases. By correlating two-photon images with conventional histopathological findings, the atlas serves as a practical reference for both clinicians and researchers seeking to integrate advanced optical imaging into diagnostic workflows.
Bridging Research and Clinical Practice
The atlas covers five major categories of dermatological diseases, including:
- Skin tumors
- Inflammatory skin diseases
- Pigmentary disorders
- Metabolic skin diseases
- Connective tissue disorders
Each chapter combines clinical presentation, characteristic two-photon imaging features, and histopathological correlations, providing a structured framework for understanding disease-specific imaging signatures.
By transforming cutting-edge imaging research into a clinically accessible diagnostic resource, the atlas highlights the growing potential of two-photon microscopy in disease diagnosis, classification, treatment evaluation, and mechanistic studies.
Looking Ahead
The publication of Atlas of Two-Photon Microscopy for Skin Diseases marks not only the launch of an important academic reference, but also a new step toward the global advancement of dermatological imaging.
As dermatology continues to evolve from simply visualizing structures to assessing morphology, composition, and function simultaneously, two-photon microscopy is poised to play an increasingly important role in non-invasive precision diagnosis.
At TRANSVISTA, we are proud to support the advancement of this field through our SUPERVISION 780 two-photon skin imaging platform, helping researchers and clinicians explore high-resolution, label-free, in vivo skin imaging and accelerate the translation of cutting-edge optical technologies into clinical practice.
Source: Umer Technology
